Both clubs are in need of a result to spark life into campaigns which are in danger of fizzling out before the home stretch following bright starts under new managers, and where better to pick one up than a London derby?
Maurizio Sarri is closing in on adding striker Gonzalo Higuain to his attack but the Argentine will not sign in time to make the matchday squad on Saturday evening.
The Gunners, meanwhile, are in need of a performance having looked limp in a 1-0 defeat at West Ham last time out.
Here is how the two sides could line up this weekend…
Arsenal XI (3-4-2-1): Leno, Mustafi, Sokratis, Koscienly, Bellerin, Xhaka, Torreira, Kolasinac, Iwobi, Aubameyang, Lacazette
Chelsea XI (4-3-3): Kepa, Azpilicueta, Rudiger, Luiz, Alonso, Jorginho, Kante, Kovacic, Pedro, Willian, Hazard
Source: Evening Standard