The Citizens, who last scored more than eight goals in a game a little over three decades ago, can now afford to rotate their squad during this busy period.
Manchester City look to be free of injury troubles, with De Bryune and Aguero raring to go once again; Mendy however is still unavailable.
Youngsters like Phil Foden and Philippe Sandler will hope to get an opportunity to showcase their abilities.
Guardiola has promised to field a strong lineup, which will be music to the ears of Gabriel Jesus, who will have another chance to add to his impressive goal tally this year.
As for Burton, they are likely to be without Scott Fraser as the midfielder was taken off injured in the draw with Doncaster at the weekend.
Preview: Burton Albion vs Manchester City – prediction, team news, lineups
Burton Albion will welcome Manchester City to the Pirelli Stadium for the second leg of the Carabao Cup semi-final on Tuesday.
Burton have the impossible job of overcoming a 9-0 defeat, but they can have a real go at the Premier League champions knowing they have very little to lose.
The Albion will be hoping City will treat the game as a dead rubber to give themselves any semblance of a chance to cause an upset.
Guardiola would have liked to have completely changed his squad for this dead rubber of a match, but that has been complicated by the EFL’s refusal to shift the Under-23s’ EFL Trophy quarter-final with Sunderland
That game is due to take place 24 hours before City’s senior side travel to the Pirelli Stadium, but Guardiola hinted at the weekend that the first team takes priority so a number of youngsters can still expect a call-up on Wednesday.
Clough is otherwise expected to name a near full-strength side, knowing that fielding a weakened XI will lead to further embarrassment.
Even reaching this stage of the competition for the first time in their history is a massive achievement in itself for Burton, but the humiliation of losing by nine goals – even against one of the best sides in world football – may take a while to recover from.
Albion knocked out three Championship clubs and one from the Premier League en route to booking their place in the final four, including Burnley at the Pirelli Stadium in September, though they more than met their match in a ruthless Man City side.
Nigel Clough’s men were still somehow in the game with half an hour of the first leg played, trailing by one goal, only for three quickfire strikes in the final 15 minutes of the half to take it away from them, before five more goals followed in the second period.
Man City were always clear favourites to brush aside Burton and reach successive EFL Cup finals for the first time in their history, but the manner of their first-leg destruction was still pretty eye-catching.
Gabriel Jesus bagged four of the nine goals, while Kevin De Bruyne, Oleksandr Zinchenko, Phil Foden, Kyle Walker and Riyad Mahrez were also on target in a one-sided clash.
Burton’s only shot on target at the Etihad Stadium came via Lucas Akins seven seconds into the match, and now it is simply a case of damage limitation for the Brewers over the remaining 90 minutes of the tie.
Collins; Brayford, Buxton, Turner, Hutchinson; Wallace, Quinn, Templeton; Akins, Boyce, Harness
Muric; Bolton, Garcia, Sandler, Zinchenko; Foden, Delph, Bernabe; Mahrez, Touaizi, Jesus
TV channel, live stream online coverage and highlights
The match will be shown live on Sky Sports’ Premier League and Main Event channels, and is available via Now TV with a day pass on offer for £7.99. Sky Sports subscribers can stream the match online via SkyGo and the SkyGo app.
You can also follow the action with NewGersy Sport’s LIVE blog.