Holders Chelsea host last year’s runners-up Manchester United in the what is the glamour tie of the round.
But the Cup’s romance in on show once again as Newport County take on Man City after beating Championship side Middlesbrough.
The League Two side, who defeated Leicester City in the previous round, stand to make a seven-figure sum from their second FA Cup in successive seasons.
Elsewhere, League One Doncaster will welcome Premier League side Crystal Palace to the Keepmoat Stadium.
AFC Wimbledon’s reward for beating West Ham is a home tie with Millwall, who also shocked Premier League opposition on Saturday.
While Frank Lampard’s Derby travel to either Brighton, with that match being played on Wednesday night.
Bristol City will host Wolves, while Swansea are at home to Brentford after they defeated fellow Londoners Barnet at the second attempt.
QPR, meanwhile, will welcome Watford to Loftus Road after their replay victory over Portsmouth.
Source: Evening Standard