Many a United fan feared the draw when the Red Devils were pitted against the French giants in December.
But since then Jose Mourinho has been sacked and Ole Gunnar Solskjaer is riding a wave of positivity with an unbeaten run.
PSG have never won the trophy that their owners crave more than any other, and the loss of Neymar could be crucial to their chances this year as two of Europe’s most feared attacks go head to head.
Both sides will be looking to their French World Cup-winning stars – United to Paul Pogba and PSG to Kylian Mbappe – to spark their European hopes as the knockout stages get underway.
Manchester United caretaker manager Ole Gunnar Solskjaer believes his side are facing Paris Saint-Germain at the perfect time as their outstanding run of form continues.
When the draw for this match was made in December, few gave Jose Mourinho’s United much chance of advancing beyond the Champions League’s last 16.
But United have been transformed since Solskjaer replaced the Portuguese, winning 10 and drawing one of his 11 games in charge.
United’s surge under Solskjaer has seen them force their way into the Premier League’s top four, but they remain unfancied in the Champions League.
Team News Manchester United vs PSG
Solskjaer’s only current injury absences are Matteo Darmian, Antonio Valencia and Marcos Rojo, meaning he will be able to field a first-choice starting XI against PSG.
The United caretaker coach rested Marcus Rashford and Jesse Lingard against Fulham, so expect the duo to form a front three along with Anthony Martial.
Chris Smalling impressed verus Fulham and could be pushing Phil Jones for a starting role alongside Victor Lindelof, who was also rested at the weekend.
As for PSG, Thomas Tuchel will be without his star man Neymar, with the Brazil forward out of both legs against Man Utd due to a metatarsal injury.
Edinson Cavani was forced off with a thigh injury against Bordeaux the Saturday before the first leg and is also out along with Thomas Meunier, who is on the sidelines due to concussion.
Kylian Mbappe, who was rested ahead of Tuesday’s trip to Old Trafford came onto replace the Uruguay international.
Marco Verratti also started and is in contention to do so against United having recovered from an ankle injury suffered back in early January.
The Italy international played for 58 minutes before he was replaced by Leandro Paredes.
Manchester United vs PSG predicted line-ups
PSG XI (4-2-3-1): Buffon; Kehrer, Kimpembe, Silva, Bernat; Marquinhos, Verratti; Alves, Draxler, Di Maria; Mbappe
Man Utd XI (4-3-3): De Gea; Young, Lindelof, Jones, Shaw; Matic, Herrera, Pogba; Lingard, Rashford, Martial
Score prediction: Man Utd 2-1 PSG
TV channel and live stream, and online coverage
The match will be televised live on BT Sport 2 and BT Sport 4K UHD. BT Sport subscribers will be able to stream the match online via the video player and the BT Sport app.
You can follow all the action with NewGersy Sport’s LIVE blog with MAS. at Old Trafford.
The two sides have, surprisingly, yet to meet each other in an official Uefa competition.
United finished second in Group G (behind Juventus) to qualify for the last-16, while PSG topped Group C ahead of Liverpool to reach the knockout stages