While Maurizio Sarri’s side picked up a first-leg win in their Europa League last 32 clash with Malmo on Thursday.
The memories of last Sunday’s 6-0 hammering at Manchester City are still fresh in the memories of Blues fans.
United meanwhile was humbled and outclassed by Paris Saint-Germain in their Champions League clash last Tuesday with Ole Gunnar Solskjaer suffering his first defeat since taking over as interim boss.
The Norwegian has entered a crucial run of fixtures that could decide whether he gets the permanent job – with the visit of Liverpool following Monday’s trip to the capital.
Alexis Sanchez and Romelu Lukaku could get the chance to start when Manchester United travel to Chelsea in the fifth round of the FA Cup on Monday (kick-off 7.30pm).
Injuries to Jesse Lingard and Anthony Martial means there is an opportunity for the likes of Sanchez and Lukaku to feature.
Both of whom have been largely restricted to bench duty under Ole Gunnar Solskjaer.
The caretaker manager said: “It’s a chance for anyone who plays if it’s Alexis or Romelu or who starts or [Tahith] Chong or Angel [Gomes].
Team News of Chelsea vs Manchester United
Chelsea has no fresh injury concerns ahead of Monday’s clash with and will give a late fitness test to Ruben Loftus-Cheek.
Blues midfielder Loftus-Cheek missed Thursday’s Europa League trip to Malmo having suffered a recurrence of his persistent back problem.
Left-back Marcos Alonso could return after being omitted from Maurizio Sarri’s squad for the trip to Sweden.
Anthony Martial and Jesse Lingard have been ruled out for up to three weeks after suffering muscle injuries in the first half against PSG.
While it serves as a huge blow, it provides an opportunity for forwards Alexis Sanchez and Romelu Lukaku to rediscover their goalscoring touch.
Solskjaer said it also opens doors for attacking youngsters Angel Gomes and Tahith Chong, who have been pushing for first-team action this season.
Antonio Valencia and Matteo Darmian are the only other absentees because of minor injuries.
Provisional squad: Kepa, Caballero, Azpilicueta, Zappacosta, Emerson, Alonso, Christensen, Luiz, Rudiger, Ampadu, Jorginho, Kante, Barkley, Loftus-Cheek, Kovacic, Hudson-Odoi, Willian, Hazard, Pedro, Higuain, Giroud.
Provisional squad: De Gea, Romero, Grant, Dalot, Shaw, Young, Jones, Bailly, Smalling, Lindelof, Fred, Matic, Herrera, McTominay, Pereira, Pogba, Mata, Sanchez, Lukaku, Rashford, Chong, Gomes.
Score prediction: Chelsea 2-1 Manchester United
TV channel and live stream, and online coverage
The match will be televised live in the UK on BBC One. A live stream will also be available on the BBC Sport website.
You can also follow all the action with NewGersy Sport’s LIVE blog.
This will be the 14th FA Cup tie between Chelsea and Manchester United – the Blues have triumphed in each of the last four, including the final last season.
There have been 181 meetings between these two giants of English football over the years.
Manchester United have 84 wins to their name compared to Chelsea’s 54.
The Blues have lost just two of the last 17 meetings, however.