The pair both hold unwanted European Cup records – Juventus have finished as runners-up seven times, more than any other team in the competition’s history.
While Atletico is the only team to reach three finals without ever winning the tournament.
For the Spanish side though, there is an extra inspiration for victory at the Wanda Metropolitano on Wednesday; should they make it to the final.
They will be back in their home stadium which will host the showpiece game for the first time.
Two European heavyweights meet in the Champions League 16 stage with Atletico Madrid hosting Juventus in Wednesday’s first leg tie.
After so much recent heartbreak in this competition, Atletico is hoping to reach this year’s final which is being held at their own Wanda Metropolitano.
Juventus are looking to reach their third final in five years after losing to Barcelona in 2015 and Real Madrid in 2017.
Juventus are running away with Serie A as they chase an eighth straight domestic title, and their 13-point lead over Napoli may well prove unassailable.
That has left their focus strongly on the Champions League – and Paulo Dybala, whose five goals in the competition so far have helped the club to their fifth last-16 clash in a row, thinks they can put that focus to good use and go all the way.
Team news of Atletico Madrid vs Juventus
Atletico coach Diego Simeone says Diego Costa is not fit to play the entire match. Costa returned to action last weekend after being sidelined for nearly two months because of a foot injury that required surgery.
He came off the bench in Atletico’s 1-0 win at Rayo Vallecano in the Spanish league on Saturday, playing alongside Alvaro Morata for the first time.
Simeone said Tuesday that Costa “is not ready to play the 90 minutes” in the round-of-16 match at Wanda Metropolitano Stadium.
Victor “Vitolo” Machin started against Rayo, but Simone did not give any hints about his formation for the first leg against Juventus.
Midfielder Jorge “Koke” Resurreccion is expected to be back in the lineup after a long injury layoff, although Simeone said he will wait until Wednesday to decide whether to start him.
Juventus coach Massimiliano Allegri says Paulo Dybala will start, but Sami Khedira has been ruled out because medical tests revealed he had an irregular heartbeat.
Allegri started his news conference on Tuesday by announcing that Dybala would be in the starting lineup for the first leg at Atletico’s Wanda Metropolitano Stadium.
He did not reveal the rest of the starting lineup, although Cristiano Ronaldo was expected to be playing in his first game in Madrid since joining Juventus from Real Madrid last summer.
Atletico Madrid possible starting lineup:
Oblak; Arias, Godin, Gimenez, Luis; Koke, Rodri, Thomas, Saul; Griezmann, Morata
Juventus possible starting lineup:
Szczesny; Cancelo, Bonucci, Chiellini, Sandro; Pjanic, Matuidi, Khedira; Ronaldo, Dybala, Mandzukic
Score prediction: Atletico Madrid 1-1 Juventus
TV channel and live stream, and online coverage
The match will be televised live on BT Sport 3.
BT Sport subscribers will be able to stream the match online via the video player and the BT Sport app.
YOU CAN FOLLOW MATCH HERE
This will be just the third meeting between these two sides.
After being paired in the group stage during the 2014-15 season, Arda Turan’s goal secured a win for Atletico at the Vicente Calderon.
Atletico traveled to Italy and left with a point after a goalless draw