The Gunners needed to beat BATE Borisov on Thursday night after losing the first leg 1-0, and Unai Emery’s side secured a 3-0 win to reach the next stage of the competition.
Arsenal return to domestic matters on Sunday against struggling Southampton.
Ralph Hasenhuttl’s side are winless in three, but the Saints beat Arsenal 3-2 at St Mary’s earlier this season and will be confident of giving the Gunners an open game in north London.
Laurent Koscielny is a doubt for Arsenal when they host Southampton in the Premier League on Sunday (kick-off 2pm).
The defender limped off during Thursday’s 3-0 Europa League win over BATE Borisov and could miss the clash against struggling Saints.
Arsenal head coach Unai Emery said it was a precaution and Koscielny will be assessed ahead of the game.
Sokratis Papastathopoulos replaced Koscielny against BATE and is likely to start as Arsenal aim to maintain their top-four challenge.
Team News of Arsenal vs Southampton
Arsenal will be sweating on the fitness of captain Laurent Koscielny. The defender limped off during Thursday’s 3-0 Europa League win over BATE and could miss the clash against struggling Saints.
Striker Alexandre Lacazette is available after missing that victory through suspension while midfielder Ainsley Maitland-Niles will be hoping to overcome illness to be involved as forward Danny Welbeck (ankle).
Right-back Hector Bellerin and defender Rob Holding (both knee) remain sidelined.
Arsenal will be sweating on the fitness of Koscielny, but striker Alexandre Lacazette is available after missing the Europa League victory through suspension.
Midfielder Ainsley Maitland-Niles will be hoping to overcome illness to be involved as forward Danny Welbeck (ankle), right-back Hector Bellerin and defender Rob Holding (both knee) remain sidelined.
Mario Lemina and Danny Ings are out for Southampton with injuries, but Stuart Armstrong and Michael Obafemi could be in contention.
Line Up of Arsenal vs Southampton
Arsenal XI: Leno; Maitland-Niles, Mustafi, Koscielny, Kolasinac; Xhaka, Torreira, Guendouzi, Ramsey, Aubameyang, Lacazette
Provisional squad: Leno, Cech, Maitland-Niles, Jenkinson, Lichtsteiner, Koscielny, Mustafi, Papastathopoulos, Mavropanos, Monreal, Kolasinac, Xhaka, Elneny, Torreira, Guendouzi, Iwobi, Suarez, Mkhitaryan, Aubameyang, Lacazette, Nketiah.
Score prediction: Arsenal 2-1 Southampton
TV channel and live stream, and online coverage
The match will not be available to watch live in the UK.
But you can follow all the action with Standard Sport’s LIVE blog from Emirates Stadium.
The teams have met 39 times in the Premier League, with Arsenal winning 21 games, Southampton seven, and the sides sharing 11 draws.
The last time the two sides met, the Saints won 3-2 at St Mary’s back in December.