Ander Herrera, Juan Mata and substitute Jesse Lingard were all taken off during a costly 22-minute period before half-time.
Rather limiting Ole Gunnar Solskjaer’s options in a high-profile affair that finished goalless.
That result, while extending the Norwegian’s impressive undefeated domestic run as caretaker manager at Old Trafford, saw United slip to fifth as rivals Arsenal secured a simple victory over Southampton.
Next opponents Palace are currently on a real high having sealed a big 4-1 away win at Leicester on Saturday to further ease any lingering relegation concerns.
Now six matches unbeaten across all competitions, the Eagles, whose 71-year-old manager Roy Hodgson is now the oldest in top-flight history, are six points clear of danger in 13th and may even have designs on a top-half finish.
They also contest an FA Cup quarter-final against Watford next month.
Ole Gunnar Solskjaer is facing an injury crisis with up to 10 players set to miss Manchester United’s Premier League trip to Crystal Palace on Wednesday (kick-off 8 pm).
Team News of Crystal Palace vs Manchester United
As if bolstering their top-four chances at Selhurst Park was not hard enough, United are having to deal with a glut of absentees.
Anthony Martial, Nemanja Matic and Phil Jones missed Sunday’s goalless draw with Liverpool,
when Ander Herrera, Juan Mata and Jesse Lingard were forced off during an extraordinary first half.
Palace have problems in defence after Mamadou Sakho limped off at the King Power Stadium due to the recurrence of a knee injury.
Martin Kelly missed the win over Leicester with a slight muscle strain and impressive right-back Aaron Wan-Bissaka is dealing with a hamstring problem.
Julian Speroni, Pape Souare and Connor Wickham are Hodgson’s other injury concerns.
United could well be without Mata, Herrera and Lingard (all hamstring) on Wednesday.
While Anthony Martial is doubtful after suffering a setback in his recovery from a groin issue and Marcus Rashford soldiered on with a swollen ankle against Liverpool.
Nemanja Matic missed the game altogether after sustaining a muscle injury in training that is expected to keep him sidelined for several weeks.
With all those problems in mind, Scott McTominay and Andreas Pereira should continue to deputise in midfield alongside Paul Pogba, with Fred potentially earning a rare start.
Alexis Sanchez and Romelu Lukaku are likely to have to shoulder the offensive load and it would not be a surprise to see one or two youngsters promoted to the bench.
Predicted Crystal Palace XI: Guaita, Ward, Tomkins, Dann, Van Aanholt, McArthur, Milivojevic, Schlupp, Townsend, Batshuayi, Zaha
Predicted Manchester United XI: De Gea; Young, Smalling, Lindelof, Shaw; Fred, Pogba, McTominay; Pereira, Lukaku, Sanchez
Score prediction: Crystal Palace 1-2 Manchester United
TV channel and live stream, and online coverage
The match will not be available to watch live in the UK.
But you can follow all the action with NewGersy Sport’s LIVE blog from Selhurst Park.
The teams have met 19 times in the Premier League, with Palace yet to record a single victory.
United boast 15 wins, while there have been four draws – including a dour stalemate at Old Trafford in November.
After that goalless draw, Jose Mourinho, who was sacked less than a month later, publicly questioned his players’ heart.