The city celebrated winning their second consecutive EFL Cup on Sunday
but their focus now shifts back to league matters with Jurgen Klopp’s side leading them by a single point following Sunday’s goalless draw with Manchester United.
Liverpool is in action against Watford at Anfield the same night.
Manuel Pellegrini makes his first return to Manchester City since his sacking in 2016 when his West Ham side visit the Etihad.
Pellegrini was sacked as City boss two years after leading them to their second Premier League title.
and defended his tenure and the effect FFP had on his time at the Etihad in the build-up to his return on Wednesday night.
Manchester City come into the game fresh from winning the first major silverware of the season with penalty shootout triumph over Chelsea in the final of the Carabao Cup on Sunday.
They can potentially cap a fine week by going top of the Premier League if they better Liverpool’s result, with the Reds hosting Watford on Wednesday night too.
Team News of Manchester City vs West Ham
Pep Guardiola will be without to key men in Fernandinho and Aymeric Laporte after both limped off during Sunday’s final at Wembley.
The City boss expects both men to be out for “some weeks.”
Gabriel Jesus meanwhile has missed the last two games with a thigh problem while John Stones is hoping to return to the squad after a recent groin injury.
Manuel Lanzini is set to be on the bench again when West Ham travel to City,
having made his first appearance of the season as a sub against Fulham on Friday after recovering from a torn ACL.
Fabian Balbuena (knee) is back in training but will not be involved until the weekend at the earliest.
while fellow defender Winston Reid has also begun light training – although he is some weeks from returning from his long-term knee injury.
Jack Wilshere, Andriy Yarmolenko and Carlos Sanchez are still sidelined.
Gabriel Jesus, Benjamin Mendy and Fabian Delph join Stones in being doubts for the match.
which means that Guardiola could be forced to play the likes of Sergio Aguero, Kevin De Bruyne and David Silva from the start again.
There are more options to rest players elsewhere, though, and both Leroy Sane and Riyad Mahrez will be hoping for recalls.
West Ham, meanwhile, handed a long-awaited return to Manuel Lanzini against Fulham.
although he is unlikely to be risked from the start so soon after coming back from such a lengthy injury.
Line Up Manchester City vs West Ham
Man City possible starting lineup:
Ederson; Danilo, Otamendi, Kompany, Zinchenko; De Bruyne, Gundogan, D Silva; Mahrez, Aguero, Sane
West Ham possible starting lineup:
Fabianski; Zabaleta, Diop, Ogbonna, Cresswell; Antonio, Noble, Rice, Snodgrass, Anderson; Arnautovic
Score prediction: Man City 3-0 West Ham
TV channel and live stream, and online coverage
The match will not be available to watch live in the UK.
But you can follow all the action with NewGersy Sport’s LIVE blog.
This will be the 109th meeting between the two clubs with City winning 54 of those meetings – including the last six.
West Ham have 37 wins to their name with 17 draws over the years