Colin had to come off with a tight hamstring during the defeat at Hull. The French defender may also miss the home game with Millwall on Wednesday.
Wes Harding is expected to replace Colin at right-back as Blues look for their first league win against Villa since March 2005.
On-loan Villa midfielder Gardner is ineligible to play against his parent club under the terms of his season-long transfer.
Villa will make the short trip without defender Tommy Elphick. The 31-year-old ruptured a tendon in his foot during the impressive 4-0 home win over Derby and he is set for a spell on the sidelines.
In Elphick’s absence, Neil Taylor is expected to be recalled at left-back, with Kortney Hause potentially moving across to play alongside Tyrone Mings in central defense.
John McGinn is available again after suspension and Villa boss Dean Smith must decide whether he goes straight back into the team.
Should McGinn be restored to the starting line up, Glenn Whelan is the man most likely to make way.
There’ll be more than just three Championship points at stake when Birmingham City host Aston Villa on Sunday.
Team News of Birmingham City vs Aston Villa
Birmingham City and Aston Villa both have injuries to contend with ahead of their Second City derby at St Andrew’s.
Wes Harding is expected to come in for Maxime Colin (hamstring) at right back and Gary Gardner is ineligible to face his parent club under the terms of the midfielder’s season-long loan.
Villa are without defender Tommy Elphick, who ruptured a foot tendon in the 4-0 home win over Derby.
But they have midfielder John McGinn available again after suspension.
Glenn Whelan is the man most likely to make way, while Kortney Hause may move across to partner Tyrone Mings in central defence, which would earn a recall for Neil Taylor at left-back.
Villa have not lost to Blues in the league since Emile Heskey and Julian Gray scored in a 2-0 win at St Andrew’s in March 2005.
Garry Monk’s Blues start the day ahead of Villa, two points better off – but an away win, to match the 4-2 victory over Blues for Dean Smith’s men in November,
would mean a leapfrogging of places for the two sides in the Championship table.
Villa may well have got the better of their neighbours back in November when they won 4-2 at Villa Park, but Blues sit two points ahead of their rivals going into the game at St Andrew’s.
To celebrate the 127th meeting of the sides, we’ve compiled a special quiz on significant events in their previous games.
Score Prediction: Birmingham City 1-1 Aston Villa
What time is the Birmingham v Aston Villa game?
Birmingham v Aston Villa will kick off at 12:00pm on Sunday 10th March 2019.
How to watch and live stream Birmingham v Aston Villa
You can watch the game live on Sky Sports Football from 11:30am. Sky Sports subscribers can also stream the match via the SkyGo app.
If you don’t have Sky, you can watch the match through NOW TV. You can get a Sky Sports day pass for £8.99, a week pass for £14.99 or a month pass for £33.99,
all without needing a contract. NOW TV can be streamed through a computer or apps found on most smart TVs, phones and consoles.
Birmingham have won just one of their last 15 matches in all competitions against Villa.
Villa are unbeaten in their previous six league visits to St Andrew’s. Each of the past three have been draws.
Blues manager Garry Monk has won more matches against Villa during his managerial career (six) than against any other club.
Villa boss Dean Smith has won four of his past five Championship meetings with Birmingham (D1).