The Saints lost their last game to Burnley in bizarre circumstances, while Villa suffered a last-minute defeat to Tottenham Hotspur on Sunday.
Aston Villa have taken just eight points from 39 on the road this season, but may fancy their chances against the team with the league’s worst home record.
Southampton’s stellar away form has carried them on the brink of safety, but Villa would be three points behind them with a win at St Mary’s.
Southampton are going to be without Nathan Redmond, sidelined for a minimum of a month,
while Sofiane Boufal and loanee Kyle Walter-Peters also miss out.
For the visitors, defender Tyrone Mings is out there again after missing the defeat to Spurs with tonsillitis.
A Bjorn Engels error allowed Heung-Min Son to seal the win, but Villa also showed some good attacking play and still scored twice against one among the league’s best sides.
Tyrone Mings will return to the starting lineup before Saturday’s meeting which should help bring more security at the rear ,
but the absence of Wesley and John McGinn has been hurting their attacking play.
Villa have picked up just eight points on the road all season, managing two wins and conceding 26 goals.
Sheffield Wednesday vs Manchester City Team News
Southampton are going to be without attacking players Nathan Redmond and Sofiane Boufal on Saturday,
with Redmond unlikely to feature again until next month.
Boufal’s absence isn’t expected to be so long-term, while loan signing Kyle Walker-Peters has also been ruled out.
Jan Bednarek could return to the starting 11 after being left on the bench last outing .
Tom Heaton and Wesley won’t be seen again this season after both suffered long-term knee injuries last month.
McGinn is closing in on a return but will still not be seen for a couple of more weeks,
while Keinan Davis and Jed Steer also are out.
Southampton’s on-loan defender Kyle Walker-Peters will miss Saturday’s game due to a calf problem.
Sofiane Boufal is out with the ankle complaint he sustained against Burnley,
while Nathan Redmond remains sidelined by a hamstring injury.
Tyrone Mings will return in defence for Aston Villa after recovering from tonsillitis.
Forward Keinan Davis is thanks to start training on Monday following his hamstring issue.
Sheffield Wednesday vs Manchester City Line Up
Southampton possible starting lineup:
McCarthy; Valery, Stephens, Bednarek, Bertrand; Armstrong, Ward-Prowse, Hojbjerg, Djenepo; Ings, Long
Aston Villa possible starting lineup:
Reina; Konsa, Mings, Hause; Guilbert, Nakamba, Luiz, Targett; El Ghazi, Samatta, Grealish
Sheffield Wednesday vs Manchester City Head-to-head
Southampton can equal their longest Premier League streak versus Aston Villa:
three matches from 1993 to 1994, and again between 1999 and 2000.
Villa are winless in seven matches against Southampton altogether competitions since a 3-2 triumph at St Mary’s in December 2013 (D3, L4).
How to follow Sheffield Wednesday vs Manchester City
This match will not be shown live in the UK.
Alternatively you can follow our live blog.
The FA Cup Fifth Round.
Wednesday 04 March, 2020